How To Avoid Viagra Professional Side-Effects?
To diagnose erectile dysfunction, determine its possible causes and choose an adequate treatment, a man needs to collect a complete medical history and conduct a thorough physical examination. Sexual activity represents a certain risk in the presence of heart disease. In this regard, before beginning any therapy for erectile dysfunction with Viagra Professional, a doctor may consider it necessary to examine patient’s cardiovascular system.
Viagra Professional that is intended for the treatment of erectile dysfunction should be used with caution in patients with anatomical deformation of penis (e.g., angulation, cavernous fibrosis or Peyronie’s disease) and in people suffering from diseases that predispose to the development of priapism (such as sickle cell anemia, multiple myeloma or leukemia).
Viagra Professional should not be prescribed to men for whom sexual activity is undesirable. The safety and effectiveness of Viagra Professional in combination with other drugs designed to treat erectile dysfunction have not been studied. In this regard, the use of such combinations is not recommended. Viagra Professional does not affect the time of bleeding, including when prescribed in combination with aspirin. Medical studies indicate that sildenafil enhances anti-aggregation effect of sodium nitroprusside (donor nitrogen oxide). Information about the safety of Viagra Professional usage in patients with diseases accompanied by bleeding, or exacerbation of peptic ulcer is not available at the moment. In this regard, such patients should use Viagra Professional with caution. A small number of patients with hereditary retinitis pigmentosa or other hereditary disorders of the phosphodiesterase activity of the retina are present. Information about the safety of Viagra Professional use in patients with pigment retinitis is not available at the moment. In this regard, such patients should use Viagra with caution.
Viagra Professional is contraindicated to patients with hypersensitivity to any component of the tablet. Due to the known influence on the exchange of nitrogen oxide, the drug intensifies hypotensive effect of nitrates; therefore, its use is contraindicated to patients administering nitrogen oxide donators or nitrates in any forms. Safety of the use of sildenafil in the following subgroups of patients has not been studied, and therefore, its use in them is contraindicated until further information is obtained: difficult hepatic insufficiency, hypotension (arterial pressure <90/50 mm Hg), recent stroke or myocardial infarction and hereditary degenerative diseases of the retina, such as retinal pigmentation (a small number of such patients have genetic disorders of retinal phosphodiesterase).
Viagra Professional is not intended for use in women. The reproductive studies in rats and rabbits with oral administration of sildenafil did not show a teratogenic effect, did not affect reproductive function, and did not cause impairment of peri/postnatal development of the fetus and newborn. A single intake of Viagra Professional in a dose of 100 mg by healthy volunteers was not accompanied by a change in the motility or morphology of spermatozoa.
In clinical trials that have been conducted worldwide, Viagra Professional has been used in more than 3700 patients (aged 19 to 87). In placebo-controlled clinical trials, the incidence of discontinuation of therapy due to adverse events was low and comparable to that of placebo. Undesirable effects were usually transient and mild or moderate. In studies with any design, the nature of adverse events in patients administering Viagra Professional was similar. In studies with fixed doses, the occurrence of adverse events was increased with growing doses. In studies with the selection of doses selected (similar studies better reflect the recommended scheme of use), the nature of adverse events was comparable to that in the studies with fixed doses. In clinical studies, with individual selection of doses, the following undesirable phenomena were most often encountered the connection of which with taking the drug was possible, probable or unknown:
- cardiovascular – headache, hot flashes, dizziness;
- digestion – indigestion;
- breathing – nasal congestion;
- sensory organs – change in visual perception (mild and transient, mainly color change of objects, as well as increased perception of light and impaired vision).
When using the drug at doses exceeding the recommended levels, the adverse events were similar to those noted above, but were usually more common. Cases of priapism are not noted. In studies in healthy volunteers with a single dose of the drug in doses up to 800 mg, adverse events were comparable to those of Viagra in lower doses, but were more common. In case of an overdose, standard symptomatic measures should be taken. Dialysis should not accelerate the clearance of sildenafil, since the latter actively binds to plasma proteins and is not cleared with urine.