Viagra Professional Active Ingredient & Formula
Viagra Professional is a well-known and time-honored drug for increasing potency in men. Initially, this remedy was developed for treatment of cardiac pathologies, but during the medical research it was discovered that it had a miraculous effect on male reproductive system. One tablet of Viagra Professional is able to return to men their sexual power and to maintain a powerful erection for several hours.
With prolonged use of this drug, there is a considerable improvement in erectile function and increased potency. What is the reason for high effectiveness of the drug? To help understand this issue, we suggest studying the constituent components of the drug and their basic properties. After reviewing characteristics of a product, each person will be able to see its useful qualities and evaluate it before purchasing from any online drug store at an affordable price and on favorable terms.
The active substance of Viagra Professional is sildenafil which promotes the release of nitrogen oxide in cavernous bodies of penis during sexual stimulation. Sildenafil is a strong selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). The effectiveness of its action lies in the increase in blood flow to penis by relaxing smooth muscle cells of the cavernous bodies and vasodilation of blood vessels.
Sildenafil is a means of peripheral action (selective inhibitor of cyclo-guanosine monophosphate (cGMP) – specific phosphodiesterase type 5 (PDE5)). It is used as an erectile stimulant with vasodilating ability. The result of its action lies in providing blood filling of the cavernous tissue of penis, preventing the outflow of blood from this tissue and causing the maximum hardness of male sexual organ (erection) provided that sexual stimulation is performed. Sildenafil does not have a direct relaxing effect on a cavernous body, but acts by increasing the production of nitrogen oxide and taking relaxing effect on cavernous spaces. During sexual response, sildenafil leads to release of nitrogen oxide and to inhibition of PDE5 resulting in the increase in the level of cGMP, relaxation of smooth muscles and intensification of blood filling of cavernous bodies in penis.
Given PDE5 is contained not only in cavernous body of penis, but also in blood vessels of lungs, the effectiveness of sildenafil application as an inhibitor of PDE5 in pulmonary hypertension (narrowing of lumen of lung vessels) was proven during clinical studies. The mechanism of sildenafil action contributing to the expansion of blood vessels of lung tissue, as well as in the treatment of erectile dysfunction, lies in the activity of nitrogen oxide. According to multiple clinical trials, superiority of sildenafil on PDE5 was found to be many times greater than the one of other PDE isoenzymes.
Sildenafil is characterized by a high absorption capacity after administration. This agent is bio-accessible by 40%. Its maximum concentration in blood after application of 100 mg on an empty stomach is 18ng/ml gets reached within the period of 30-120 minutes. However, it should be taken into account that eating fatty food negatively affects the absorption of sildenafil and is characterized by an elongation of Tmax by 60 minutes. Sildenafil undergoes metabolism under the influence of microsomal isoenzymes of liver with the formation of pharmacologically active N-dimethyl which is subject to further biotransformation. Elimination half-life period (T1/2) of sildenafil in the terminal phase is 3-5 hours. The agent is mainly cleared with fecal masses in the form of metabolites (80%), approximately 13% of the total is cleared by excretory function of the kidneys (with urine). It should be borne in mind that patients belonging to the geriatric group due to age-related changes affecting the rate of physiological reactions in the body may experience significant decrease of sildenafil clearance and increase of blood concentration (by 40%).
Patients with renal insufficiency may have changes in pharmacokinetic characteristics that directly depend on the severity of nephropathology. If a man takes Viagra Professional only once, not more than 50 mg of the remedy is allowed. For mild and moderate forms of kidney disorders, the pharmacokinetic parameters do not change. In severe nephron adhesions, the clearance of sildenafil is markedly reduced; the AUC and Cmax values are increased by 100% and 88%, respectively, relative to patients of the same age without a history of nephropathology. In cirrhosis, the clearance of sildenafil decreases, AUC and Cmax values increase by approximately 84% and 47%, respectively, compared with patients of similar age without hepatopathy.
The composition of Viagra Professional pill comprises not only sildenafil, but also some auxiliary substances, such as:
- microcrystalline cellulose;
- anhydrous calcium hydrogen phosphate;
- croscarmellose sodium;
- magnesium stearate.
The components of the drug acting in combination cause enhanced blood flow to penis and thus prolong and strengthen erection contributing to the improvement of the quality of sexual activity and its prolongation. The composition of Viagra Professional tablets includes all the components necessary to ensure that the drug effectively cures all forms of erectile dysfunction, including a complete loss of potency. It goes without saying that Viagra Professional is not an artificial stimulant; therefore, after taking the remedy, erection will occur only upon the condition of psychological arousal, that is, sexual stimulation. This drug for increasing potency causes minimal side-effects (headache, blood rush to the head, minor eye disorders) that occur only in some men taking Viagra Professional. Most of the representatives of stronger sex tolerate the drug well. Contraindications to taking medication include the presence of chronic pathologies and individual intolerability of substances that are contained in the tablet of Viagra Professional. In this regard, before using the remedy, men are recommended consulting a specialist and undergoing a comprehensive examination.
These tablets to increase the potency are a reliable and proven means to struggle against erectile dysfunction and sexual impotency which was experienced by millions of men from all around the world. If a person has problems of sexual nature, he should not give up and doom himself to an inferior life. When ordering Viagra Professional in online pharmacy, a man can test its effectiveness and benefits, and restore his sexual power and steady natural erection. A wide range of quality products to increase potency are nowadays offered by Canadian online stores that guarantee complete anonymity and provide all conditions for a comfortable purchase.